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KMID : 0370219970410030283
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Yakhak Hoeji
1997 Volume.41 No. 3 p.283 ~ p.293
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Synthesis and Antitumor Activity of Antineoplaston A10 Analogs as potential Antineoplastic Agents
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최보길/Choi BG
서희경/김옥영/정병호/오인준/조원제/천승훈/박민수/Seo HK/Kim OY/Chung BH/Oh IJ/Cho WJ/Cheon SH/Park MS
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Abstract
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Some analogs and their Mannich bases of Antineoplaston A10 (A10) were synthesized. Chemical yield for the 2-(or 3-)thienyl, benzol, and phenylpropionyl analogs were high but 1-n aphthyl analog was synthesized in low yield. the Mannich bases formation of these analogs with morpholine went verywell compared to other bases. 1-Naphthyl, 4-nitrobenzoyl, and phenylpropionyl analogs of A10 showed weak in vitro activity but the other A10 analogs showed weaker or no activity at 10-1000mcg/ml. But their Mannich bases containing A10analogs showed good in vitro activity compared to simple A10 analogs.
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